News: Processium is Moving !!!

News: Processium is Moving !!!

News

Founded in 2002 by engineers coming from the chemical industry, Processium is an independent company employing about forty collaborators and specialized in design, development and optimisation of processes for chemical and biotechnological industries. Processium provides services for the biggest industrial companies and also supports the industrialisation of projects coming from innovative start-up.

 

Processium has high-level team of experts, laboratories dedicated to analysis, measurements and laboratory scale pilot units. Processium participates actively, in particular within the framework of collaborative research projects, in miscellaneous European technical and business clusters and associations.

 

Processium has created in 2014 a subsidiary located on the scientific campus of Unicamp (São Paulo State, Brazil), and strengthens its commercial presence in Europe and in North America. To come along with this development, Processium is moving into its new premises which are located Immeuble « Le 380 », 30 rue Marguerite, 69100 Villeurbanne, France. This new building is lacating in the same place its team of experts and enhance its technical means with, in particular, a new technological and demonstration hall which will allow Processium to validate experimentally the processes, to produce samples and to accommodate the pilots of its customers.

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News: DEINOVE announces the success of its cosmetic active ingredient’s production process industrialization

News: DEINOVE announces the success of its cosmetic active ingredient’s production process industrialization

News

DEINOVE (Euronext Growth Paris: ALDEI), a biotech company that discovers, develops, and produces high-value compounds from rare bacteria, notably from the Deinococcus genus, announces having produced the first industrial batch of its innovative carotenoid.
As announced in December, the scale-up of the fermentation production process was carried out on the technological platform of the BIOGIS Center at SAS PIVERT. After a technology transfer stage, a first production of several cubic meters was successfully completed. The biomass produced followed an original and environmentally-friendly process, developed in collaboration with PROCESSIUM, for extraction, purification, and formulation, resulting in the first industrial batch of the end product. DEINOVE selected VEG’EXTRA, a specialist in extraction, as a provider for these downstream processing steps.

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News: Deinove launches the industrial production of its first carotenoid

News: Deinove launches the industrial production of its first carotenoid

News

DEINOVE (Euronext Growth Paris: ALDEI), a biotech company that discovers, develops, and produces high-value compounds from rare bacteria, notably from the Deinococcus genus, announces the launch of the industrial production of its first carotenoid. The company's fermentation platform has developed an optimized process in terms of performance and robustness on a 20-liter scale. At the same time, the collaboration with Processium lead to the definition of the downstream process of extraction, purification, and formulation, and the drafting of the "Process Book" detailing its implementation.

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Case study: Measurements of density, heat capacity, viscosity and thermal conductivity on heat transfer fluids up to 250°C

Case study: Measurements of density, heat capacity, viscosity and thermal conductivity on heat transfer fluids up to 250°C

Specialty Chemicals, Oil and Gas, Fine Chemicals

PROJECT DESCRIPTION

Our customer wishes to characterize thermophysical properties (heat capacity, vapour pressure, viscosity, density, thermal conductivity, etc.) of new heat transfer fluids used in a wide range of temperatures.

TECHNICAL CHALLENGES

Our teams of experts conducted tests on the fluids with in mind the temperature dependence of each property in order to optimise the number of experimental points to reduce the cost for the client.

RESULTS

A complete mapping of physical properties to provide technical datasheet of each thermal fluid.

viscosity-curve
thermal-conductivity-curve
heat-capacity-curve
Case study: Deactivation test on catalysts

Case study: Deactivation test on catalysts

Industrial Biotechnlogy, Specialty Chemicals, Oil and Gas, Natural Ingredients, Fine Chemicals

PROJECT DESCRIPTION

Our customer wishes to know the kinetic of deactivation of its catalyst under industrial conditions in order to adapt the sizing of corresponding process accordingly. In addition to this, the definition of the frequency of replacement of the catalyst was also an issue to secure productivity.

TECHNICAL CHALLENGES

Test should be performed continuously over hundreds of hours on a reactive mixture under conditions which precisely represent the operating conditions (temperatures over 250°C and pressures of 6 bar).

The test needed to implement a dedicated bench to test the catalyst in continuous mode.

OUR METHODOLOGY

  • Design and development of a continuous reaction bench equipped with a tubular reactor working in conditions close to those of the process (6 bar and 250°C).
  • Regular sampling from the reactor for 30 days.
  • Analysis of the samples to obtain a follow-up of the kinetic of deactivation.
  • Definition of a reliable kinetic model integrating a term of deactivation.

RESULTS

Sizing of the process is adapted according to this new model. The frequency of replacement of catalyst is also defined on the basis of the model.

This model allows to secure the annual production of several thousand tons of products.

News: DEINOVE: the industrialization process of the carotenoids program enters Phase II

News: DEINOVE: the industrialization process of the carotenoids program enters Phase II

News

In November 2016, DEINOVE launched the shift from laboratory to industrial scale, accompanied by the company Processium* . The first phase of this program consisted of:

  • Selecting and characterizing a first carotenoid that will be market-ready, validating both its biological properties and its economic potential;
  • Optimizing the production strain and increasing the yields in the laboratory, with a view to obtaining a strain suitable for industrial production;
  • Evaluating the various extraction processes in order to define the best one in industrial production conditions.

This phase I has been conducted successfully.

  • A first molecule has been selected for its innovative feature, with the goal of obtaining a competitive advantage on the market. DEINOVE has demonstrated its total safety, but also its antioxidant and healing properties, which position this first molecule as particularly favorable for cosmetic applications.
  • The carotenoid-producing strain was optimized and tested in fermenters of up to 20 liters. The yields obtained were significantly higher than the target yields, ensuring the economic viability of the production process.
  • The work carried out with the company Processium led to the evaluation of various extraction and purification techniques available on the market. It is now necessary to validate the performance of these techniques in order to prepare the transition to the industrial scale. The first laboratory-scale tests yielded an extract with a purity level suited for an actual commercialization.

The quality of the results obtained makes it possible to start phase II of this program, which aims to validate all the technical conditions and to select the subcontractors best suited for production at an industrial scale. This phase II should continue until the end of 2017 and lead to the production of the first batches of this carotenoid.

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Case study: Debottlenecking of batch process

Case study: Debottlenecking of batch process

Specialty Chemicals

PROJECT DESCRIPTION

The Client produces ester in a batch process (reaction + distillation column). Processium services were requested to enhance unit productivity by decreasing the duration of each batch. Improvement of co-product quality is also requested and part of the Project.

OUR METHODOLOGY

The first task issued by Processium was a statistical study on process data issued from SNCC to identify the reasons for dysfunction among all parameters (quality of reactants, temperature, stoechiometry, …). This study highlighted several parameters responsible of malfunctions of the unit. Thanks to the management of these identified parameters during production, productivity increased of 5%.

Following this first study, Processium conducted a new study based on kinetics and thermodynamics measurements, development of corresponding models and process optimization using ASPEN simulation.

RESULTS

Unit had been debottlenecked (10%) without investment, purity of the co-product improved (97% to 99%). In addition, Processium also proposed technical investments to reach additional 20% potential debottlenecking.

Case study: Odour removal

Case study: Odour removal

Specialty Chemicals

PROJECT DESCRIPTION

The Client uses distillation to purify an added value product. One of the impurity is an odorous molecule that causes two limitations:

  • the product can not be supplied for specific application because of the smell given to the product by the odorous impurity,
  • in order to limit the quantity of odorous impurity in the product, the yield of purification has to remain low.

The Client asks to Processium to identify a technical solution to retain the odorous impurity  in the bottom of the distillation column.

OUR METHODOLOGY

To be able to propose technical solutions, Processium developed the following methodology:

  • identification of a technical solution (bibliography, internal know-how),
  • screening of existing activated carbons using in-house database including exhaustive data on possible suppliers,
  • development of a design of experiments to minimize experimental work (amount of carbon, number of batches, temperature),
  • experimental trials conducted on several activated carbons under different conditions according to the developed design of experiments,
  • sizing of industrial unit operation.

RESULTS

Processium issued a recommendation report describing the selected technology and corresponding operating conditions. In addition to the removal of odorous impurity for the product, distillation yield was improved (25% increase of productivity).

Case study: Challenging a newly developed process

Case study: Challenging a newly developed process

Specialty Chemicals

PROJECT DESCRIPTION

The Client has developed a new process to treat a waste stream:

  • possible unit operations are chosen,
  • theoretical mass and thermal balances are available, theoretical sizing is also available,
  • CAPEX and OPEX estimate is issued.

The Client asks to Processium to challenge the developed process in order to secure its operability, its productivity and to minimize uncertainities during its industrialisation

OUR METHODOLOGY

For each unit operation, Processium studies:

  • the relevance of the technology,
  • its performances (expected yield and purity),
  • Its limitations.

The process, as a whole, is studied to fully understand the product specifications, the yield, and all process limitations.

RESULTS

Processium issued a recommendation report containing explanation on:

  • an "alert" on impurity accumulation on a recycling loop,
  • a risk of reaction on activated carbon,
  • an uncertainty on thermodynamics (impact on distillation feasibility),
  • an optimization to reduce energy consumption.
News: Processium New offices in Villeurbanne

News: Processium New offices in Villeurbanne

News

Processium development comes along with the construction of new premises which will locate in the same place its team of experts and enhance its technical means with, in particular, a new technological and demonstration hall which will allow Processium to validate experimentally the processes, to produce samples and to accommodate the pilots of its customers.

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