Experimental study on refrigerant blends to replace R-134a in mobile air conditioning
Call of Project ADEME
MELCOO Project (2005) and F3PRG Project

Innovation
This Project targeted refrigerant fluids replacement by more sustainable fluids. Processium brought its know-how on Computer Aided Molecular Design (CAMD) to successfully determine a list of possible product candidates. This experimental study had been executed by CNAM_IFFI, RENAULT, PROCESSIUM and SPIREC (MELCOO) and CNAM, LISA, LOA, IMMOSTEF and PROCESSIUM (F3PRG).
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Project methodology to develop intensification of processes
Call of Project ANR CD2I
PROCIP Project (01/2011 – 12/2014)

Innovation
The aim of this collaborative Project is to develop a methodology of technical project management to be able to support the decision in the frame of the intensification of processes. Industrialy, the intensification of processes has to allow to decrease time to market for a product by designing the most optimal process in term of energy consumption, safety, environmental impacts, investment cost, etc. The main objective of the "PROCIP" Project is thus to develop of a general methodology dedicated to intensification of processes. This includes the implementation of a software as well as its validation via improved experimental techniques. To reach these objectives, multidisciplinary competences are necessary (process expertise, modelling know-how, competences in process intensification, project management skills and good knowledge of cost estimates). and its leads to the creation…
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Efficient development of industrial chemical processes
Call of Project FUI 20
DEEPER Project (10/2015 – 09/2018)

Innovation
The objective of DEEPER Project is to develop services dedicated to efficient design of industrial chemical processes integrating innovative technologies targeting specialty and fine chemicals industries. The services will include the implementation of intensified technologies and will lean on digital tools and a technical expertise. The purpose is to adopt methods for the development of more afficient processes and the integration of process intensification. The time requested for the development can be reduced, while adopting technologies which will aim at a minimum environmental impact. The methodology to support the choice of technologies will be developed by taking into account the combination of unit operations and the kind of activation. In parallel, studies will be led to validate the methods used for data acquisition. Then, the following step will be focused…
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Development and applications of computer model dedicated to REACH regulation
Call of Project FUI 17
DAMIER Project (07/2014 – 06/2017)

Innovation
The objective of DAMIER Project is to replace some of experimental studies currently requested for the recording of chemical substances according to REACH regulation by an IT modelling of the physico-chemical and écotoxicological data. This modelling is established on the use of QSAR models (Quantitative Structure - Activity Relationship), which have three major advantages: Reduction of the cost of constitution of REACH files (up to 40 %) Time savings regarding the execution of studies (3 months for the experimental studies against few days for the QSAR models) Limitation of experiments involving living animals (fishes). Although the QSAR models are tools recommended by the European Agency of Chemicals (ECHA), the majority of existing models were designed for screening and are not considered as acceptable for REACH regulation because of their lack…
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Bioprocesses for the optimized, integrated production of butyl esters from sustainable resources
Call of Project ERA-CoBioTech
BESTER Project (04/2018 – 03/2021)

Innovation
The ERA-CoBioTech project BESTER establishes clostridial bioprocesses for an optimized integrated production of a range of different butyl esters using lignocellulosic sugars as a sustainable feedstock for the commodity chemicals market. Efficient organic acid production processes will be developed, which can be linked to ABE fermentation processes as a source of BuOH. BESTER will thereby address in a coordinated way the two key handles for efficient production of the three acids, i.e. a) Systems biology driven strain engineering using Synthetic biology principles to establish new acid production in suitable clostridial chassis strains and mitigate key metabolic bottlenecks hampering high productivity, and b) smart process design and integration to prevent inhibitory effects of the acids produced and the BuOH added in efficient bioprocesses with continuous enzymatic ester product formation and recovery.…
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