<strong>Deactivation test on catalysts</strong></br>Case Study

Deactivation test on catalysts
Case Study

Industrial Biotechnlogy, Specialty Chemicals, Oil and Gas, Natural Ingredients, Fine Chemicals
  PROJECT DESCRIPTION Our customer wishes to know the kinetic of deactivation of its catalyst under industrial conditions in order to adapt the sizing of corresponding process accordingly. In addition to this, the definition of the frequency of replacement of the catalyst was also an issue to secure productivity. TECHNICAL CHALLENGES Test should be performed continuously over hundreds of hours on a reactive mixture under conditions which precisely represent the operating conditions (temperatures over 250°C and pressures of 6 bar). The test needed to implement a dedicated bench to test the catalyst in continuous mode. OUR METHODOLOGY Design and development of a continuous reaction bench equipped with a tubular reactor working in conditions close to those of the process (6 bar and 250°C). Regular sampling from the reactor for 30 days.…
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Case study: Ethanol purification process

Case study: Ethanol purification process

Natural Ingredients
PROJECT DESCRIPTION The Client is a specialist of natural ingredients extracted from biomass and dedicated to cosmetic and pharmaceutical markets. The solvent (ethanol) used for the extraction is regenerated by the Client on its own industrial plant. Processium was in charge to develop a process for the regeneration of ethanol, and to determine the best operating conditions: to insure the robustness of the process to manage the variability of impurities, to respect the conformity of the solvent to standarts (impurity < ppm). Furthermore, the Client wishes to avoid any investment, or at least to limit the amount. OUR METHODOLOGY After a process synthesis phase, it had been decided to develop an adsorption process (carbon black) followed by a distillation (the equipment already exists on Client plant). Processium proposed a methodology devided into three phases: Phase 1: Processium made measurements to determine the performances of…
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Case study: Fractionation of a lipidic excipient

Case study: Fractionation of a lipidic excipient

Natural Ingredients
PROJECT DESCRIPTION The Client develops specialised raw materials for the pharmaceutical and cosmetic industries such as lipidic excipients. A neutral basis is produced from oil and from additives thanks to a transesterification reaction. This neutral basis is conditioned in the form of capsules. However, one of the residual additives reacts with the envelope of the capsule and damages its mechanical properties. Thus the Client wishes to reduce the content of this residual additive from 30 % to 5 %. Processium was in charge of the process technical feasibility study to eliminate the additive. OUR METHODOLOGY The methodology developed by Processium was based on: Process synthesis to propose processes able to purify the neutral basis. Identification of solvents able to extract the additive. Sizing of the best process. Laboratory and pilot scale validation of process sizing.…
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Case study: Risk assessment of a chemical reaction thermal runaway

Case study: Risk assessment of a chemical reaction thermal runaway

Industrial Biotechnlogy, Specialty Chemicals, Oil and Gas, Natural Ingredients, Fine Chemicals
  PROJECT DESCRIPTION The Client wishes to implement a new chemical reaction on industrial site under the SEVESO directive. Processium brought them its know-how into thermal analyses to evaluate the risks of thermal runaway of this reaction. TECHNICAL CHALLENGES The challenges met in this project are the following ones: Non-available physico-chemical data, Complex products implementation, Measurements under pressure up to about 5 bar. OUR METHODOLOGY Processium carries out this study from drawing-up the specifications to the measurements of all properties: Vapor pressure of reagents and products, Thermal stability: decomposition temperature (Tonset), time to maximum rate (TMRad), Reaction kinetics, Reaction enthalpy, Heat capacity, Maximum Temperature of the Synthesis Reaction (MTSR), Nature and gas flow released during the reaction. RESULTS The measured data define the level of criticality of the chemical reaction and…
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Case study: Vapor-liquid equilibria of solvent and light hydrocarbons

Case study: Vapor-liquid equilibria of solvent and light hydrocarbons

Industrial Biotechnlogy, Specialty Chemicals, Oil and Gas, Natural Ingredients, Paints and Coatings, Fine Chemicals
  PROJECT DESCRIPTION The objective of this study is to acquire data to design an extractive distillation process for separating light hydrocarbons. TECHNICAL CHALLENGES A key element of success in the study is the measurement of vapor-liquid equilibria at pressures of 2 to 5 bar, to determine the liquid and vapor compositions in a mixture of heavy and light components (boiling point difference > 230°C). OUR METHODOLOGY We undertook this study by: Developing efficient analytic methods, Developing a suitable experimental strategy to acquire measurements in line with customer’s project and time constraints. RESULTS The measurements were carried out successfully in our labs, and Processium was able to provide: A feedback on notable issues encountered, particularly degeneration of seals or corrosion problems Data values which allowed our customers to better understand their…
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Case study: Vapor-liquid-liquid equilibria of vegetable oil/methanol/glycerol

Case study: Vapor-liquid-liquid equilibria of vegetable oil/methanol/glycerol

Industrial Biotechnlogy, Specialty Chemicals, Oil and Gas, Natural Ingredients, Paints and Coatings, Fine Chemicals
  PROJECT DESCRIPTION Our client conducted a study of biodiesel conversion and separation in which our teams provided essential thermodynamic expertise for the design of the process. TECHNICAL CHALLENGES The objective of this study was to obtain liquid-liquid-vapour equilibria measurements for a complex mixture. This study involved: Thermodynamic measurements on viscous mixtures at high pressure Very complex sampling protocol as a result of the differences in volatility of the compounds (methanol-glycerol) and the operating conditions A complex analysis process due to the nature (vegetable oil) and the physical properties of the compounds OUR METHODOLOGY Processium successfully completed this study by using: A customized experimental strategyallowing timely data acquisition in line with client project requirements Objectivity and a wider perspectivein interpreting the obtained results to precisely understand the behaviour of client compounds.…
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Case study: Prediction of physico-chemical data

Case study: Prediction of physico-chemical data

Industrial Biotechnlogy, Specialty Chemicals, Oil and Gas, Natural Ingredients, Paints and Coatings, Fine Chemicals
  PROJECT DESCRIPTION Our client, a manufacturer of synthetic oils, wishes to determinate the vapor pressure and the boiling point of oil’s constituents in order to design and optimize their production processes. TECHNICAL CHALLENGES The challenges met in this project are the following ones: Presence of considerable number of compounds in each oil, whose properties are unknown (high cost for carrying out measurements) Difficulty of separation and purification of these synthetic oils: it is impossible to access to pure compound OUR METHODOLOGY The method of physico-chemical data prediction, specifically developed for this project, allows to free itself from properties measurement of these products. It consists in the following steps: Definition of a customized decomposition method for these synthetic oils Evaluation and sorting of available data based on the specifications. The e-thermoTM…
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Case study: Solvent selection

Case study: Solvent selection

Industrial Biotechnlogy, Specialty Chemicals, Oil and Gas, Natural Ingredients, Paints and Coatings, Fine Chemicals
  PROJECT DESCRIPTION Our client has developed a production process of organic acids by fermentation. Organic acids need to be extracted and purify from the broth using a solvent extraction technology. TECHNICAL CHALLENGES In order to satisfy client requirements for its Project, Processium had to to identify a bio-based solvent for the extraction of acids and able to preserve microbes used for fermentation. OUR METHODOLOGY The methodology developed by Processium for the successful development of the Project had been developed as follow: screening of in - house database containing more than 1,000 industrial solvents data sets, identification of additional candidate determined thanks to a specific Computer Aided Molecular Design tool, modeling of solvent properties and prediction of missing data, identification of 5 solvents and measurement of distribution coefficients, performance evaluation of solvents…
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Case study: Salts solubility in water

Case study: Salts solubility in water

Industrial Biotechnlogy, Specialty Chemicals, Oil and Gas, Natural Ingredients, Paints and Coatings, Fine Chemicals
  PROJECT DESCRIPTION Our customer wishes to know the solubility of a solid inorganic salt in an aqueous solution at 80 °C. The influence of pH of this solution on the solubility of the salt must be estimated. Measures are led at 3 different hydrogen potential by going from pH 4 (acidic), pH 7 (neutral) and to pH 9 (basic). TECHNICAL CHALLENGES Why do we speak about challenges? For two main reasons:The solubility of the salt in the liquid is very high. The first difficulty is to identify an analytical methodology adapted to the inorganic solid. ICP-AES had been selected as the most accurate technique for the analysis of this molecule and was successfully used. Thermogravimetry study was coupled with a specific chemical analysis to insure reliability of the supplied results because of…
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