Thermodynamics and Kinetics Measurement

During your process design, development or optimisation phases, you need to secure your data on thermodynamics and kinetics. In its laboratories, Processium is able to develop reliable methodologies to make thermodynamics measurement like:

  • Vapour and sublimation pressure
  • Fluid phase equilibria for mixtures
  • Azeotrope determination (composition and temperature)
  • Activity coefficients at infinite dilution
  • Gas and solid solubility measurements
  • Supercritical vapor-liquid equilibria
  • Excess enthalpies of mixing

Operating conditions: 10-4 Pa < P < 107 Pa,  -40°C < T < 300 °C

If requested, Processium has also a proven experience in thermodynamic modelling and, generally speaking, of  of key physico-chemical properties requested for process design.

Processium also provides reproducible results on kinetics for reactor design, but also dedicated to process safety and security issues:

  • Homogeneous reaction kinetics
  • Heterogeneous reaction kinetics (liquid-gas, liquid-solid, catalyzed)
  • Heat of reaction
  • Reaction monitoring to identify degradation kinetics and product
  • Thermal stability (Tonset, TMRad)

Our Case Studies

  • Prediction of physico-chemical data to characterize synthetic oils
  • Vapor-liquid-liquid equilibria of vegetable oil/methanol/glycerol up to 200°C for biodiesel production
  • Vapor-liquid equilibria of solvent and light hydrocarbons at 2,5 bar
  • Risk assessment of a chemical reaction thermal runaway
  • Thermodynamic data requested for the sizing of a purification process
  • Vapor-liquid equilibria of refrigerant mixtures up to 35 bar (PTxy)
  • Liquid-liquid equilibria of methanol/water/ether/salts at 1 bar (PTxx’)
  • Vapour-liquid equilibria of electrolytes systems at 50 mbar (PTxy)
  • Vapor-liquid-liquid equilibria of hydrogen sulfide/mercaptan/water at 4 bar (PTxx’y)
  • Activity coefficient measurements for screening absorption solvents
  • Gas solubility measurements of hydrogen sulfide in an acetamide at 25 °C
  • Enthalpies of mixing between acrylic acid and methyl ethyl ketone at 105 °C at 5 bar
  • Vapor-liquid equilibria of supercritical gases up to 90 bar (PTxy)
  • Vapor-liquid-solid equilibria of natural gases down to -40°C
  • Liquid-solid equilibrium and determination of eutectic composition down to -70°C
  • Solubility of inorganic salts in chlorhydric acid solutions up to 160°C (PTx)
  • Solubility of O2, N2, H2, HCl, Cl2, NH3, H2S, NOx, COin various liquids up to 30 bar (PTx)
  • Vapor-liquid equilibria of peroxide mixtures between 10 and 50 mbar (PTx)
  • Esterification and transesterification kinetic measurements up to 230°C
  • Measurements of kinetics for hydrogenation of alkenes at 20 bar
  • Measurements of Kinetics of Chlorination at -10°C
  • Pressure impact on azeotrope composition to design a pressure swing distillation

Our Key Elements of Success


Expertise in Thermodynamics


Development of Specific Apparatus


Expertise in Process Engineering


Reliability of Results

Our Equipment

Static-synthetic / Total Pressure Technique

static synthetic total pressure technique

Operating range:

  • Temperature: -20 to 200 °C
  • Pressure: 0.1 mbar to 1 bar
  • Material of construction: Glass


  • Pure component and mixture boiling point measurements
  • Bubble point measurements

Dynamic-analytic / Ebulliometry


 Operating range:

  • Temperature: < 250 °C
  • Pressure: 5 mbar to 1 bar
  • Material of construction: Glass


  • Pure component boiling point measurements
  • Vapour-liquid equilibrium measurements
  • Vapour-liquid-liquid equilibrium measurements
  • Degradation kinetics

Static-analytic Technique

static synthetic total pressure technique2

 Operating range:

  • Temperature: < 280 °C
  • Pressure: 0.1 to 100 bar
  • Material of construction: Sapphire


  • Pure component boiling point measurements
  • Vapour-liquid equilibrium and vapour-liquid-liquid equilibrium measurements with phase analysis, for sizing and separation units
  • Can be used with a total pressure technique
  • Reaction kinetic rates for reactor sizing



 Operating range:

  • Temperature: 20 to 250 °C
  • Pressure: 1 to 2.5 bar
  • Material of construction: Glass


  • Batch distillation for determination of azeotrope composition and temperature
  • Purification of raw samples to obtain a higher purity compound for subsequent experiments



 Operating range:

  • Temperature: 25 to 90 °C
  • Pressure: 1 bar
  • Material of construction: Glass


  • Solvant selection for absorption and stripping processes
  • Measures the activity coefficient at infinite dilution – key variable for sizing separation units designed for high purity operations

DSC and Calorimetry

dsc and calorimetry

 Operating range:

  • Temperature: < 300 °C for calorimetry, -80 to 700 °C for DSC
  • Pressure: 1 to 500 bar
  • Material of construction: Stainless steel


  • Thermal stability (Tonset, TMRad)
  • Heat of reaction (batch, fed batch or continuous mode)
  • Kinetic conversion curve for Homogeneous and Heterogeneous Reaction (liquid-gas, liquid-solid, catalyzed)

Reactor with on-line Analysis


 Operating range:

  • Temperature: < 280 °C
  • Pressure: 1 to 100 bar
  • Material of construction: Sapphire


  • Homogeneous reaction kinetic measurements for reactor sizing
  • Thermal stability or reaction monitoring to identify degradation kinetics and product

Liquid Solubility Cell

cellule solubilite retouche

 Operating range:

  • Temperature: 0 to 100 °C
  • Pressure: 1 bar
  • Material of construction: Glass


  • Determination of extractive solvent selectivity
  • Liquid-liquid equilibrium measurements
  • Solid-liquid equilibrium measurements
  • Decantation kinetics rates



 Operating range:

  • Temperature: <300 °C
  • Pressure: 1 to 200 bar
  • Material  of construction: Hastelloy


  • Homogeneous reaction kinetics
  • Heterogeneous reaction kinetics (liquid-gas, liquid-solid, catalyzed)

Should you need any additional information on our offer, do not hesitate to contact us